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Issue 6, 2016
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Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging

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Abstract

Biocompatible nanoparticles of gadolinium-incorporated Prussian blue with the empirical formula K0.94Gd0.02Fe[Fe(CN)6] exhibit extremely high stability against the release of Gd3+ and CN ions under the acidic conditions similar to stomach juice. The high r1 relaxivity, low cytotoxicity and the ability of such nanoparticles to penetrate the cell membrane suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted oral cellular MRI probes for the early detection of tumors in the gastrointestinal tract.

Graphical abstract: Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging

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Article information


Submitted
10 Sep 2015
Accepted
05 Feb 2016
First published
05 Feb 2016

Analyst, 2016,141, 2016-2022
Article type
Paper
Author version available

Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging

V. S. Perera, G. Chen, Q. Cai and S. D. Huang, Analyst, 2016, 141, 2016
DOI: 10.1039/C5AN01873K

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