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Issue 2, 2016
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Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

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Abstract

In the last several years, nanoscale vesicles that originate from tumor cells and which can be found circulating in the blood (i.e. exosomes and microvesicles) have been discovered to contain a wealth of proteomic and genetic information to monitor cancer progression, metastasis, and drug efficacy. However, the use of exosomes and microvesicles as biomarkers to improve patient care has been limited by their small size (30 nm–1 μm) and the extensive sample preparation required for their isolation and measurement. In this Critical Review, we explore the emerging use of micro and nano-technology to isolate and detect exosomes and microvesicles in clinical samples and the application of this technology to the monitoring and diagnosis of cancer.

Graphical abstract: Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

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Publication details

The article was received on 06 Aug 2015, accepted on 07 Sep 2015 and first published on 08 Sep 2015


Article type: Critical Review
DOI: 10.1039/C5AN01610J
Analyst, 2016,141, 450-460

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    Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

    J. Ko, E. Carpenter and D. Issadore, Analyst, 2016, 141, 450
    DOI: 10.1039/C5AN01610J

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