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Issue 41, 2015
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Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

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Abstract

Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture.

Graphical abstract: Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

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Publication details

The article was received on 29 Jun 2015, accepted on 17 Aug 2015 and first published on 19 Aug 2015


Article type: Review Article
DOI: 10.1039/C5TB01276G
J. Mater. Chem. B, 2015,3, 8032-8058

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    Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

    A. Higuchi, Q. Ling, S. S. Kumar, Y. Chang, A. A. Alarfaj, M. A. Munusamy, K. Murugan, S. Hsu and A. Umezawa, J. Mater. Chem. B, 2015, 3, 8032
    DOI: 10.1039/C5TB01276G

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