Facile synthesis of magnetic core–shell nanocomposites for MRI and CT bimodal imaging

Jing Zhu; Jiaqing Wang; Xin Wang; Jingfen Zhu; Yanmei Yang; Jian Tian; Wenguo Cui; Cuicui Ge; Yonggang Li; Yue Pan; Hongwei Gu

doi:10.1039/C5TB00775E

Facile synthesis of magnetic core–shell nanocomposites for MRI and CT bimodal imaging†

Jing Zhu,^a Jiaqing Wang,^a Xin Wang,^b Jingfen Zhu,^b Yanmei Yang,^c Jian Tian,^c Wenguo Cui,^d Cuicui Ge,^c Yonggang Li,^b Yue Pan*^a and Hongwei Gu*^a

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* Corresponding authors

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, China
E-mail: hongwei@suda.edu.cn, panyue@suda.edu.cn

^b Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China 215006

^c School for Radiological and Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, China

^d Orthopedic Institute, Soochow University, China

Abstract

With the development of nanotechnology, nanocomposites have been used as bimodal contrast agents for magnetic resonance (MR) and computed tomography (CT) imaging. We have developed a facile method for the synthesis of iron oxide@bismuth sulfide magnetic core–shell nanocomposites. These bifunctional nanocomposites can be made water-soluble via PEG coating and present strong MRI/CT contrast enhancement. Evaluation of cytotoxicity by MTT assay shows that the nanocomposites have low cytotoxicity. The results illustrate that the nanocomposites have great potential as bimodal imaging agents for MR/CT.

Journal of Materials Chemistry B

Facile synthesis of magnetic core–shell nanocomposites for MRI and CT bimodal imaging†

Abstract

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Facile synthesis of magnetic core–shell nanocomposites for MRI and CT bimodal imaging

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