Issue 27, 2015
From the journal:

Journal of Materials Chemistry B

Intracellular pH-induced fluorescence used to track nanoparticles in cells†

F. R. Cheng,ab   Y. Chen,c   T. Su,a   H. Cao,d   S. Li,c   J. Cao,*a   B. He,a   Z. W. Gua  and  X. L. Luo*b  

* Corresponding authors

a National Engineering Research Center for Biomaterials, Sichuan University, 29# Wangjiang Road, Chengdu 610064, China
E-mail: caojun@scu.edu.cn
Fax: +86-28-85412923
Tel: +86-28-85412923

b College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
E-mail: luoxl@scu.edu.cn

c College of Chemical Engineering, Sichuan University, Chengdu 610065, China

d Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350116, China

Abstract

A nanoparticle with pH-induced fluorescence was reported for intracellular tracking. The fluorescence was evoked by the isomerization of the ring-closed form spiropyran (SP) to the ring-open form merocyanine (MC) in the weak acidic environment of cells. The SP–MC switch accelerated the dissociation of nanoparticles to trigger the release of trapped paclitaxel.

Graphical abstract: Intracellular pH-induced fluorescence used to track nanoparticles in cells

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C5TB00756A
Article type
Communication
Submitted
22 Apr 2015
Accepted
19 May 2015
First published
19 May 2015

J. Mater. Chem. B, 2015,3, 5411-5414

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Intracellular pH-induced fluorescence used to track nanoparticles in cells

F. R. Cheng, Y. Chen, T. Su, H. Cao, S. Li, J. Cao, B. He, Z. W. Gu and X. L. Luo, J. Mater. Chem. B, 2015, 3, 5411 DOI: 10.1039/C5TB00756A

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