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Issue 27, 2015
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Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D

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Abstract

RGD peptides (Arg–Gly–Asp) are known to promote cell adhesion. As a consequence, numerous materials have been functionalized using these peptides for several medical applications. We report herein the controlled functionalization of surfaces to study the influence of RGD density on cell selectivity. For this purpose, we selected a quartz crystal microbalance QCM-D as this technique allows real-time monitoring of cell adhesion to RGD surfaces. We observed that a critical spacing of nearly 40 nm between RGD ligands is required to observe selective cell adhesion whereas a higher density is not specific.

Graphical abstract: Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D

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Supplementary files

Article information


Submitted
05 Mar 2015
Accepted
28 May 2015
First published
28 May 2015

J. Mater. Chem. B, 2015,3, 5577-5587
Article type
Paper
Author version available

Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D

L. Sandrin, D. Thakar, C. Goyer, P. Labbé, D. Boturyn and L. Coche-Guérente, J. Mater. Chem. B, 2015, 3, 5577
DOI: 10.1039/C5TB00420A

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