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Issue 25, 2015
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3D conducting polymer platforms for electrical control of protein conformation and cellular functions

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Abstract

We report the fabrication of three dimensional (3D) macroporous scaffolds made from poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) via an ice-templating method. The scaffolds offer tunable pore size and morphology, and are electrochemically active. When a potential is applied to the scaffolds, reversible changes take place in their electrical doping state, which in turn enables precise control over the conformation of adsorbed proteins (e.g., fibronectin). Additionally, the scaffolds support the growth of mouse fibroblasts (3T3-L1) for 7 days, and are able to electrically control cell adhesion and pro-angiogenic capability. These 3D matrix-mimicking platforms offer precise control of protein conformation and major cell functions, over large volumes and long cell culture times. As such, they represent a new tool for biological research with many potential applications in bioelectronics, tissue engineering, and regenerative medicine.

Graphical abstract: 3D conducting polymer platforms for electrical control of protein conformation and cellular functions

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Supplementary files

Article information


Submitted
28 Feb 2015
Accepted
02 Apr 2015
First published
02 Apr 2015

J. Mater. Chem. B, 2015,3, 5040-5048
Article type
Paper
Author version available

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

A. M. Wan, S. Inal, T. Williams, K. Wang, P. Leleux, L. Estevez, E. P. Giannelis, C. Fischbach, G. G. Malliaras and D. Gourdon, J. Mater. Chem. B, 2015, 3, 5040
DOI: 10.1039/C5TB00390C

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