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Issue 14, 2015
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Quatsomes for the treatment of Staphylococcus aureus biofilm

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Abstract

The anti-biofilm effect of drug delivery systems composed of the antiseptic quaternary ammonium compound cetylpyridinium chloride (CPC) and cholesterol was evaluated in Staphylococcus aureus biofilm. Self-assembly of CPC/cholesterol to approximately 100 nm CPC-quatsomes was successfully accomplished by a simple sonication/dispersion method over a broad concentration range from 0.5 to 10 mg ml−1 CPC. CPC-quatsomes showed a dose-dependent anti-biofilm effect, killing >99% of biofilm-associated S. aureus from 5% mg ml−1 after 10 minutes exposure. Cell toxicity studies with CPC-quatsomes in Nuli-1 cells revealed no adverse effects at all tested CPC concentrations. CPC-quatsomes, therefore, have a promising potential as novel drug delivery systems with “built-in” anti-biofilm activity.

Graphical abstract: Quatsomes for the treatment of Staphylococcus aureus biofilm

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Article information


Submitted
25 Nov 2014
Accepted
16 Feb 2015
First published
18 Feb 2015

J. Mater. Chem. B, 2015,3, 2770-2777
Article type
Paper
Author version available

Quatsomes for the treatment of Staphylococcus aureus biofilm

N. Thomas, D. Dong, K. Richter, M. Ramezanpour, S. Vreugde, B. Thierry, P. Wormald and C. A. Prestidge, J. Mater. Chem. B, 2015, 3, 2770
DOI: 10.1039/C4TB01953A

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