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Issue 3, 2015
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Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

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Abstract

We describe here designs of compartmentalized hydrogel microparticles with a tunable extracellular matrix (ECM) support for cell encapsulation and scalable 3D cell culture. The microparticles, rapidly formed by a one-step, multi-fluidic electrostatic spraying technique (>10 000 min−1), have a uniform spherical shape, a nearly monodisperse size distribution and controlled compartmentalization. They not only have a high surface area for mass transfer but also offer defined space and essential ECM support for various scalable and efficient 3D cell culture, co-culture and microtissue production applications.

Graphical abstract: Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

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Publication details

The article was received on 20 Oct 2014, accepted on 24 Nov 2014 and first published on 27 Nov 2014


Article type: Communication
DOI: 10.1039/C4TB01735H
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J. Mater. Chem. B, 2015,3, 353-360

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    Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

    Y. Lu, W. Song, D. An, B. J. Kim, R. Schwartz, M. Wu and M. Ma, J. Mater. Chem. B, 2015, 3, 353
    DOI: 10.1039/C4TB01735H

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