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Issue 9, 2015
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Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bone

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Abstract

Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, conductive CNT-based “smart” materials accumulate exciting grafting qualities for tuning the in vitro cellular phenotype. Biphasic electrical stimulation of human osteoblastic cells was performed in vitro on either dielectric bioactive bone grafts or conductive CNT-reinforced composites. The efficiency of the electrical stimuli delivery, as well as the effect of stimulation on cellular functions were investigated. Conductive substrates boosted the local culture medium conductivity and the confinement of the exogenous electrical fields. Hence, bone cell proliferation, DNA content and mRNA expression were maximized on the conductive substrates yielding superior stimuli delivering efficiency over dielectric ones. These findings are suggestive that bioactive bone grafts with electrical conductivity are capable of high spatial and temporal control of bone cell stimulation.

Graphical abstract: Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bone

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Publication details

The article was received on 30 Sep 2014, accepted on 08 Jan 2015 and first published on 09 Jan 2015


Article type: Paper
DOI: 10.1039/C4TB01628A
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J. Mater. Chem. B, 2015,3, 1831-1845

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    Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bone

    D. Mata, F. J. Oliveira, M. A. Neto, M. Belmonte, A. C. Bastos, M. A. Lopes, P. S. Gomes, M. H. Fernandes and R. F. Silva, J. Mater. Chem. B, 2015, 3, 1831
    DOI: 10.1039/C4TB01628A

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