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Issue 1, 2016
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Collective dynamics of processive cytoskeletal motors

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Abstract

Major cellular processes are supported by various biomolecular motors that usually operate together as teams. We present an overview of the collective dynamics of processive cytokeletal motor proteins based on recent experimental and theoretical investigations. Experimental studies show that multiple motors function with different degrees of cooperativity, ranging from negative to positive. This effect depends on the mechanical properties of individual motors, the geometry of their connections, and the surrounding cellular environment. Theoretical models based on stochastic approaches underline the importance of intermolecular interactions, the properties of single motors, and couplings with cellular medium in predicting the collective dynamics. We discuss several features that specify the cooperativity in motor proteins. Based on this approach a general picture of collective dynamics of motor proteins is formulated, and the future directions and challenges are discussed.

Graphical abstract: Collective dynamics of processive cytoskeletal motors

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Article information


Submitted
30 Jun 2015
Accepted
26 Sep 2015
First published
28 Sep 2015

Soft Matter, 2016,12, 14-21
Article type
Review Article
Author version available

Collective dynamics of processive cytoskeletal motors

R. T. McLaughlin, M. R. Diehl and A. B. Kolomeisky, Soft Matter, 2016, 12, 14
DOI: 10.1039/C5SM01609F

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