Jump to main content
Jump to site search

Issue 44, 2015

Wrapping of nanoparticles by the cell membrane: the role of interactions between the nanoparticles

Author affiliations

Abstract

A fundamental understanding of the interactions between nanoparticles (NPs) and the cell membrane is essential to improve the performance of the NP-based biomedical applications and assess the potential toxicity of NPs. Despite the great progress in understanding the interaction between individual NP and the membrane, little is known about the interaction between multiple NPs and the membrane. In this work, we investigate the wrapping of two parallel elongated NPs by the membrane, taking the NP–NP electrostatic interaction and van der Waals (vdW) interaction into consideration. Three types of NPs, namely the rigid NPs with circular and elliptic cross-sections and the deformable NPs, are systematically investigated. The results show that the electrostatic interaction would enhance the tendency of the independent wrapping and inhibit the rotation of the elongated and equally charged NPs with elliptic cross-sections. Under the vdW interaction, the competition of the NP–NP adhesion and the membrane elastic energies with the NP–membrane adhesion energy leads the NPs to be wrapped cooperatively or independently. For the system with elongated NPs with elliptic cross-sections, the NPs are more likely to be wrapped independently as the shapes become more anisotropic and the NPs would rotate to contact each other with the flat sides in the cooperative wrapping configuration. Moreover, the soft NPs are more likely to be wrapped cooperatively compared with the stiff NPs. These results may provide guidelines to control the internalization pathway of NPs and improve the efficiency of NP-based drug delivery systems.

Graphical abstract: Wrapping of nanoparticles by the cell membrane: the role of interactions between the nanoparticles

Article information


Submitted
12 Jun 2015
Accepted
01 Sep 2015
First published
01 Sep 2015

Soft Matter, 2015,11, 8674-8683
Article type
Paper

Wrapping of nanoparticles by the cell membrane: the role of interactions between the nanoparticles

H. Tang, H. Ye, H. Zhang and Y. Zheng, Soft Matter, 2015, 11, 8674 DOI: 10.1039/C5SM01460C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements