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Issue 1, 2016
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Electronic control of DNA-based nanoswitches and nanodevices

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Abstract

Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of these DNA-based nanodevices we have applied different voltage potentials at the surface of an electrode chip. The applied potential promotes an electron-transfer reaction that releases from the electrode surface a molecular input that ultimately triggers the DNA-based nanodevice. The use of electronic inputs as a way to finely activate DNA-based nanodevices appears particularly promising to expand the available toolbox in the field of DNA nanotechnology and to achieve a better hierarchical control of these platforms.

Graphical abstract: Electronic control of DNA-based nanoswitches and nanodevices

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Supplementary files

Article information


Submitted
29 Sep 2015
Accepted
12 Nov 2015
First published
12 Nov 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 66-71
Article type
Edge Article
Author version available

Electronic control of DNA-based nanoswitches and nanodevices

S. Ranallo, A. Amodio, A. Idili, A. Porchetta and F. Ricci, Chem. Sci., 2016, 7, 66
DOI: 10.1039/C5SC03694A

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    [Original citation] - Published by The Royal Society of Chemistry.

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