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Issue 12, 2015
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Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

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Abstract

We report the first cationic gold(I)-catalyzed one-pot reaction of amide, alkyne and aldehyde followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. A single catalyst allows the occurring of this multi-step reaction atom- and step-economically, with water as the only theoretical side product.

Graphical abstract: Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

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Publication details

The article was received on 09 Aug 2015, accepted on 05 Oct 2015 and first published on 06 Oct 2015


Article type: Edge Article
DOI: 10.1039/C5SC02933C
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Citation: Chem. Sci., 2015,6, 7332-7335
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    Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

    P. Querard, S. A. Girard, N. Uhlig and C. Li, Chem. Sci., 2015, 6, 7332
    DOI: 10.1039/C5SC02933C

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