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Issue 12, 2015
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Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

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Abstract

We report the first cationic gold(I)-catalyzed one-pot reaction of amide, alkyne and aldehyde followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. A single catalyst allows the occurring of this multi-step reaction atom- and step-economically, with water as the only theoretical side product.

Graphical abstract: Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

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Article information


Submitted
09 Aug 2015
Accepted
05 Oct 2015
First published
06 Oct 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 7332-7335
Article type
Edge Article
Author version available

Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

P. Querard, S. A. Girard, N. Uhlig and C. Li, Chem. Sci., 2015, 6, 7332
DOI: 10.1039/C5SC02933C

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