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Issue 1, 2016
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Next-generation disulfide stapling: reduction and functional re-bridging all in one

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Abstract

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.

Graphical abstract: Next-generation disulfide stapling: reduction and functional re-bridging all in one

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Supplementary files

Article information


Submitted
22 Jul 2015
Accepted
13 Sep 2015
First published
15 Sep 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 799-802
Article type
Edge Article

Next-generation disulfide stapling: reduction and functional re-bridging all in one

M. T. W. Lee, A. Maruani, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2016, 7, 799
DOI: 10.1039/C5SC02666K

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