Issue 11, 2015

Cobalt catalyzed sp3 C–H amination utilizing aryl azides


A dinuclear Co(II) complex supported by a modular, tunable redox-active ligand system is capable of selective C–H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C–H amination technology.

Graphical abstract: Cobalt catalyzed sp3 C–H amination utilizing aryl azides

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Article information

Article type
Edge Article
31 Mar 2015
20 Jul 2015
First published
30 Jul 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 6672-6675

Author version available

Cobalt catalyzed sp3 C–H amination utilizing aryl azides

O. Villanueva, N. M. Weldy, S. B. Blakey and C. E. MacBeth, Chem. Sci., 2015, 6, 6672 DOI: 10.1039/C5SC01162K

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