Issue 7, 2015

Copper-catalyzed diamination of unactivated alkenes with hydroxylamines

Abstract

A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with O-acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapid and efficient approach to construct a wide range of 1,2-diamines that are an important structural motif in organic synthesis, medicines, catalysts and ligands.

Graphical abstract: Copper-catalyzed diamination of unactivated alkenes with hydroxylamines

Supplementary files

Article information

Article type
Edge Article
Submitted
11 Mar 2015
Accepted
14 May 2015
First published
18 May 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 4279-4283

Author version available

Copper-catalyzed diamination of unactivated alkenes with hydroxylamines

K. Shen and Q. Wang, Chem. Sci., 2015, 6, 4279 DOI: 10.1039/C5SC00897B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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