Jump to main content
Jump to site search

Issue 3, 2015

Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

Author affiliations

Abstract

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

Graphical abstract: Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

Supplementary files

Article information


Submitted
04 Dec 2014
Accepted
24 Dec 2014
First published
24 Dec 2014

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 1640-1644
Article type
Edge Article

Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

L. Tan, H. Li, Y. Qiu, D. Chen, X. Wang, R. Pan, Y. Wang, S. X. Zhang, B. Wang and Y. Yang, Chem. Sci., 2015, 6, 1640 DOI: 10.1039/C4SC03749A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements