Issue 2, 2015

Metal complexes as potential modulators of inflammatory and autoimmune responses

Abstract

Over the past few decades, the realm of inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of transition metal complexes, particularly those based on platinum or ruthenium. However, comparatively less attention has been focused on the development of metal complexes for the treatment of inflammatory or autoimmune diseases. Metal complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses. The studies presented here serve to highlight the potential of transition metal complexes in modulating inflammatory or immune pathways in cells.

Graphical abstract: Metal complexes as potential modulators of inflammatory and autoimmune responses

Article information

Article type
Perspective
Submitted
09 Oct 2014
Accepted
07 Nov 2014
First published
07 Nov 2014
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2015,6, 871-884

Metal complexes as potential modulators of inflammatory and autoimmune responses

C. Leung, S. Lin, H. Zhong and D. Ma, Chem. Sci., 2015, 6, 871 DOI: 10.1039/C4SC03094J

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