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Issue 1, 2015

In vivo visible light-triggered drug release from an implanted depot

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Abstract

Controlling chemistry in space and time has offered scientists and engineers powerful tools for research and technology. For example, on-demand photo-triggered activation of neurotransmitters has revolutionized neuroscience. Non-invasive control of the availability of bioactive molecules in living organisms will undoubtedly lead to major advances; however, this requires the development of photosystems that efficiently respond to regions of the electromagnetic spectrum that innocuously penetrate tissue. To this end, we have developed a polymer that photochemically degrades upon absorption of one photon of visible light and demonstrated its potential for medical applications. Particles formulated from this polymer release molecular cargo in vitro and in vivo upon irradiation with blue visible light through a photoexpansile swelling mechanism.

Graphical abstract: In vivo visible light-triggered drug release from an implanted depot

Supplementary files

Article information


Submitted
29 Aug 2014
Accepted
04 Oct 2014
First published
06 Oct 2014

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 335-341
Article type
Edge Article

In vivo visible light-triggered drug release from an implanted depot

C. Carling, M. L. Viger, V. A. Nguyen Huu, A. V. Garcia and A. Almutairi, Chem. Sci., 2015, 6, 335 DOI: 10.1039/C4SC02651A

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