Synthesis of isatins by the palladium-catalyzed intramolecular acylation of unactivated aryl C(sp2)–H bonds

Abstract

Synthesis of isatins from formyl-N-arylformamides is achieved via PdCl₂-catalyzed intramolecular acylation. This method shows the possibility of Pd-catalyzed aryl C(sp²)–H bond activation on the synthesis of isatins, affording an array of isatins in good yields. Yet this protocol is operationally simple and atom economical.