Issue 127, 2015

Fluorescence response of a thiazolidine carboxylic acid derivative for the selective and nanomolar detection of Zn(ii) ions: quantum chemical calculations and application in real samples

Abstract

A thiazolidine carboxylic acid derivative (L) was conveniently synthesized and characterized by spectral techniques and single crystal X-ray crystallography. The complexation of L with zinc (L–Zn2+) was studied by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) and further substantiated by 1H NMR and ESI-MS analysis. The L showed excellent specificity and sensitivity towards a zinc-induced fluorescence response by forming a 1 : 1 complex (Job's plot) in a 95% (v/v) water–methanol mixture. The presence of zinc ions causes ∼40 fold fluorescence enhancement at 481 nm (quantum yield, Φ = 0.19) and can be detected with the naked eye under a UV-lamp. The L can detect Zn2+ in nanomolar levels (13.90 nM) with good tolerance in the presence of other interfering metal ions. The reversibility of L–Zn2+ complexation was checked by EDTA titration. The maximum fluorescence enhancement by Zn2+ binding of L was observed in the pH range of 7.0–9.0. The dissociation constants of L and the stability constant of the L–Zn2+complex in 0.15 M NaClO4 were determined by pH metrically. Theoretical calculations were done using density functional theory (DFT) to support the above findings. L was successfully applied for the determination of Zn2+ in water samples. The compound (L) detects the presence of, Klebsiella pneumoniae and E. coli in water samples.

Graphical abstract: Fluorescence response of a thiazolidine carboxylic acid derivative for the selective and nanomolar detection of Zn(ii) ions: quantum chemical calculations and application in real samples

Supplementary files

Article information

Article type
Paper
Submitted
13 Oct 2015
Accepted
06 Dec 2015
First published
09 Dec 2015

RSC Adv., 2015,5, 105453-105463

Author version available

Fluorescence response of a thiazolidine carboxylic acid derivative for the selective and nanomolar detection of Zn(II) ions: quantum chemical calculations and application in real samples

C. Balakrishnan, M. Theetharappan, S. Natarajan, S. Thalamuthu and M. A. Neelakantan, RSC Adv., 2015, 5, 105453 DOI: 10.1039/C5RA21277D

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