A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents†
Abstract
We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.