Thermo- and glucose-responsive micelles self-assembled from phenylborate ester-containing brush block copolymer for controlled release of insulin at physiological pH

Abstract

An amphiphilic brush block copolymer P(St-g-PBDEMA)-b-P(MEO₂MA-co-OEGMA) was prepared by ATRP, RAFT and click chemistry. The copolymer micelles show temperature and glucose responses. The controlled release of insulin could be achieved by adjusting temperature and glucose concentration.