Issue 127, 2015
From the journal:

RSC Advances

Silver(i)–N-heterocyclic carbene catalyzed multicomponent reactions: a facile synthesis of multisubstituted pyridines†

Shravankumar Kankala,a   Ramakanth Pagadala,a   Suresh Maddila,a   Chandra Sekhar Vasam*bc  and  Sreekantha B. Jonnalagadda*a  

* Corresponding authors

a School of Chemistry & Physics, University of Kwazulu-Natal, Westville Campus, Chiltern Hills, Durban-4000, South Africa
E-mail: jonnalagaddas@ukzn.ac.za
Fax: +27 31 260 3091
Tel: +27 31 260 7325/3090

b Department of Chemistry, Satavahana University, Karimnagar, India

c Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, India
E-mail: vasamcs@yahoo.co.in
Fax: +91-878-2255933
Tel: +91-9000285433

Abstract

A four component one-pot reaction between aromatic aldehyde, malononitrile, ammonium acetate and ketone mediated by Ag(I) N-heterocyclic carbene to produce multisubstituted and fused pyridines in a short reaction time (∼10 min) in ethanol at room temperature is described.

Graphical abstract: Silver(i)–N-heterocyclic carbene catalyzed multicomponent reactions: a facile synthesis of multisubstituted pyridines

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Article information

DOI
https://doi.org/10.1039/C5RA16582B
Article type
Paper
Submitted
17 Aug 2015
Accepted
07 Dec 2015
First published
08 Dec 2015

RSC Adv., 2015,5, 105446-105452

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Silver(I)–N-heterocyclic carbene catalyzed multicomponent reactions: a facile synthesis of multisubstituted pyridines

S. Kankala, R. Pagadala, S. Maddila, C. S. Vasam and S. B. Jonnalagadda, RSC Adv., 2015, 5, 105446 DOI: 10.1039/C5RA16582B

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