Jump to main content
Jump to site search

Issue 92, 2015
Previous Article Next Article

Catalytic applications of {[HMIM]C(NO2)3}: as a nano ionic liquid for the synthesis of pyrazole derivatives under green conditions and a mechanistic investigation with a new approach

Author affiliations

Abstract

Catalytic applications of 1-methylimidazolium trinitromethanide {[HMIM]C(NO2)3}as the first nano ionic liquid (NIL) was studied. The described NIL was efficiently tested in the synthesis of 5-amino-pyrazole-4-carbonitrile derivatives in good to excellent yields on the three-component condensation of various aromatic aldehydes, malononitrile and phenylhydrazine at room temperature under solvent-free and ambient conditions. In the next study, 1,4-dihydropyrano-[2,3-c]-pyrazole derivatives were also synthesized via four-component condensation of a good range of aromatic aldehydes, malononitrile, phenylhydrazine and ethyl acetoacetate in the presence of NIL under the same reaction conditions. The described reactions were in good agreement with the green chemistry disciplines and their major advantages are short reaction times, good yields, ease of separation, recycling and reusability of NIL. A new mechanistic approach was proposed for the final step of the pyrazoles synthesis which was supported by theoretical studies.

Graphical abstract: Catalytic applications of {[HMIM]C(NO2)3}: as a nano ionic liquid for the synthesis of pyrazole derivatives under green conditions and a mechanistic investigation with a new approach

Back to tab navigation

Supplementary files

Article information


Submitted
12 Aug 2015
Accepted
28 Aug 2015
First published
28 Aug 2015

RSC Adv., 2015,5, 75555-75568
Article type
Paper

Catalytic applications of {[HMIM]C(NO2)3}: as a nano ionic liquid for the synthesis of pyrazole derivatives under green conditions and a mechanistic investigation with a new approach

M. A. Zolfigol, F. Afsharnadery, S. Baghery, S. Salehzadeh and F. Maleki, RSC Adv., 2015, 5, 75555
DOI: 10.1039/C5RA16289K

Social activity

Search articles by author

Spotlight

Advertisements