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Issue 101, 2015
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Biocomposites for wound-healing based on sol–gel magnetite

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Currently, efficient wound-healing materials are booming due to increasing health care costs and world population aging, but also because of a sharp increase in the incidence of diabetes and obesity. Exacting demands are placed upon modern wound-healing materials as these should affect all stages of healing by accelerating them. In this paper, we demonstrate for the first time that drug entrapped magnetite xerogels can be effectively used for this purpose. To prepare a healing biocomposite, we have combined four medicaments in a magnetite matrix: chlorhexidine digluconate as an antimicrobial agent, lidocaine as a painkiller, prednisolone as an anti-inflammatory agent and chymotrypsin as a necrolytic agent. Compared to the control group, the wound healing rate with a biocomposite exhibited a ∼1.5-fold increase (21 and 14 days for complete healing, respectively). Moreover application of a magnetite-based biocomposite provided strong scar size decrease. Characteristics of the magnetite matrix as well as wound-healing composite material are fully described by XRD, XPS, SEM, TEM and N2 physisorption analysis.

Graphical abstract: Biocomposites for wound-healing based on sol–gel magnetite

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Article information

11 Aug 2015
24 Sep 2015
First published
24 Sep 2015

RSC Adv., 2015,5, 82992-82997
Article type
Author version available

Biocomposites for wound-healing based on sol–gel magnetite

A. S. Drozdov, K. V. Volodina, V. V. Vinogradov and V. V. Vinogradov, RSC Adv., 2015, 5, 82992
DOI: 10.1039/C5RA16177K

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