Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 101, 2015
Previous Article Next Article

Biocomposites for wound-healing based on sol–gel magnetite

Author affiliations

Abstract

Currently, efficient wound-healing materials are booming due to increasing health care costs and world population aging, but also because of a sharp increase in the incidence of diabetes and obesity. Exacting demands are placed upon modern wound-healing materials as these should affect all stages of healing by accelerating them. In this paper, we demonstrate for the first time that drug entrapped magnetite xerogels can be effectively used for this purpose. To prepare a healing biocomposite, we have combined four medicaments in a magnetite matrix: chlorhexidine digluconate as an antimicrobial agent, lidocaine as a painkiller, prednisolone as an anti-inflammatory agent and chymotrypsin as a necrolytic agent. Compared to the control group, the wound healing rate with a biocomposite exhibited a ∼1.5-fold increase (21 and 14 days for complete healing, respectively). Moreover application of a magnetite-based biocomposite provided strong scar size decrease. Characteristics of the magnetite matrix as well as wound-healing composite material are fully described by XRD, XPS, SEM, TEM and N2 physisorption analysis.

Graphical abstract: Biocomposites for wound-healing based on sol–gel magnetite

Back to tab navigation

Article information


Submitted
11 Aug 2015
Accepted
24 Sep 2015
First published
24 Sep 2015

RSC Adv., 2015,5, 82992-82997
Article type
Paper
Author version available

Biocomposites for wound-healing based on sol–gel magnetite

A. S. Drozdov, K. V. Volodina, V. V. Vinogradov and V. V. Vinogradov, RSC Adv., 2015, 5, 82992
DOI: 10.1039/C5RA16177K

Social activity

Search articles by author

Spotlight

Advertisements