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Issue 119, 2015

Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles

Author affiliations

Abstract

An electrostatic complexation of liposomes, composed of anionic palmitoyloleoyl phosphatidylserine (POPS1−) and zwitterionic dioleoylphophatidylcholine (DOPC), with bilayer vesicles composed of cationic poly(L-lysine)-b-poly(L-leucine) block copolypeptides has been investigated. The complexation was characterized by several physicochemical methods with the following main conclusions: (a) all added liposomes are totally adsorbed on the polypeptide vesicles up to a certain saturation concentration. (b) The calculated number of liposomes per a single polypeptide vesicle is about 60. (c) The liposomes remain intact (i.e., do not leak) after being complexed with the vesicles. (d) Complexes are stable in physiological ionic strength solution with [NaCl] = 0.15 M. (e) The vesicles are effectively digested by proteolytic enzyme trypsin even when covered by liposomes. These findings as well as the high potential for loading of anionic liposomes and cationic vesicles with biologically active compounds make these multi-liposomal complexes promising in the drug delivery field.

Graphical abstract: Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles

Supplementary files

Article information


Submitted
07 Aug 2015
Accepted
08 Nov 2015
First published
11 Nov 2015

RSC Adv., 2015,5, 98687-98691
Article type
Communication
Author version available

Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles

A. A. Yaroslavov, O. V. Zaborova, A. V. Sybachin, I. V. Kalashnikova, E. Kesselman, J. Schmidt, Y. Talmon, A. R. Rodriguez and T. J. Deming, RSC Adv., 2015, 5, 98687 DOI: 10.1039/C5RA15863J

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