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Issue 85, 2015
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DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

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Abstract

We show via 3D-heteronuclear NMR spectroscopy that Aβ1–40 adopts a disordered conformational ensemble with fluctuating turns in DMSOd6. Using NMR, we map the binding sites of three water-insoluble aggregation inhibitors to Aβ1–40 in DMSOd6 and discover remarkable differences in Aβ1–40 recognition by a fourth inhibitor in H2O versus DMSOd6.

Graphical abstract: DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

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Supplementary files

Article information


Submitted
23 Jun 2015
Accepted
10 Aug 2015
First published
10 Aug 2015

RSC Adv., 2015,5, 69761-69764
Article type
Communication
Author version available

DMSO affects Aβ1–40's conformation and interactions with aggregation inhibitors as revealed by NMR

D. V. Laurents, D. Pantoja-Uceda, L. C. López, J. A. Carrodeguas, M. Mompeán, M. Á. Jiménez and J. Sancho, RSC Adv., 2015, 5, 69761
DOI: 10.1039/C5RA12100K

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