A simple and rapid approach for testing enantiopurity of hydroxy acids and their derivatives using 1H NMR spectroscopy†
Abstract
A rapid and the simple chiral derivatizing protocol involving the coupling of 2-formylphenylboronic acid and an optically pure [1,1-binaphthalene]-2,2-diamine is introduced for the accurate determination of the enantiopurity of hydroxy acids and their derivatives, possessing one or two optically active centers, using 1H NMR spectroscopy.