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Issue 72, 2015

Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

Author affiliations

Abstract

The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies. To enable a structure–toxicity-relationship of the natural product, eleven novel synthetic derivatives with different electrochemical properties were synthesized and tested. Derivative 5 revealed a GI50 in the low μM range, being more active than the actual natural product. A clear correlation was found between the experimental and the calculated data.

Graphical abstract: Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

Supplementary files

Article information


Submitted
10 Jun 2015
Accepted
26 Jun 2015
First published
29 Jun 2015

This article is Open Access

RSC Adv., 2015,5, 58561-58565
Article type
Paper
Author version available

Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives

N. Jacobs, S. Lang, R. Panisch, G. Wittstock, U. Groth and H. R. Nasiri, RSC Adv., 2015, 5, 58561 DOI: 10.1039/C5RA11078E

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