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Issue 75, 2015
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Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents

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Abstract

Natural deep eutectic solvents (NADES) are recently developed green solvents that are attractive for their great solubilising power and intrinsic lack of toxicity. In this paper we report the results of a study on the feasibility and benefits of dissolving the poorly water-soluble salsalate in a NADES composed of 1,2-propanediol–choline–water as an alternative to DMSO for functional in vitro assays. The increase in solubility allows an extension of the range of the dose-response curve of salsalate-induced activation of brown adipocytes.

Graphical abstract: Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents

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Publication details

The article was received on 29 May 2015, accepted on 08 Jul 2015 and first published on 08 Jul 2015


Article type: Communication
DOI: 10.1039/C5RA10196D
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Citation: RSC Adv., 2015,5, 61398-61401

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    Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents

    E. Rozema, A. D. van Dam, H. C. M. Sips, R. Verpoorte, O. C. Meijer, S. Kooijman and Y. H. Choi, RSC Adv., 2015, 5, 61398
    DOI: 10.1039/C5RA10196D

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