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Issue 78, 2015
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APTES mediated modular modification of regenerated silk fibroin in a water solution

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Abstract

Silk fibroin (SF) is a natural polymer of increasing interest for applications ranging from tissue engineering to optoelectronics. Here, we report a new mild and facile strategy targeted on hydroxylic pendants of serine and tyrosine residues, to functionalize SF in water, based on the use of amino(propyl)triethoxysilane (APTES), a common silylating agent. APTES is exploited as a bifunctional linker to bind SF through the triethoxysilane α-ends and to simultaneously graft species of interest, even hydrophobic ones, by means of the end γ-amino groups. By using a fluorescent oligothiophene bearing amino reacting end groups (T3) we monitor the process simply through fluorescence detection and we demonstrate the value of the proposed method to achieve chemically modified SF materials. Moreover, we show that the new SF based biocomposite retains silk filmability and transparency but also shows T3 fluorescence and markedly enhanced mechanical robustness.

Graphical abstract: APTES mediated modular modification of regenerated silk fibroin in a water solution

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Supplementary files

Article information


Submitted
27 May 2015
Accepted
16 Jul 2015
First published
17 Jul 2015

RSC Adv., 2015,5, 63401-63406
Article type
Paper

APTES mediated modular modification of regenerated silk fibroin in a water solution

A. Sagnella, M. Zambianchi, M. Durso, T. Posati, A. Del Rio, A. Donnadio, A. Mazzanti, A. Pistone, G. Ruani, R. Zamboni, V. Benfenati and M. Melucci, RSC Adv., 2015, 5, 63401 DOI: 10.1039/C5RA10016J

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