Issue 69, 2015

Synthesis of poly-functionalized imidazoles via vinyl azides annulation

Abstract

An efficient annulation of vinyl azides with activated imines has been developed for the synthesis of poly-functionalized imidazole derivatives. This reaction includes thermal decomposition of vinyl azides to 2H-azirines, nucleophilic attack of 2H-azirines with activated imines and subsequent cyclization to desired imidazoles.

Graphical abstract: Synthesis of poly-functionalized imidazoles via vinyl azides annulation

Supplementary files

Article information

Article type
Communication
Submitted
22 Apr 2015
Accepted
19 Jun 2015
First published
19 Jun 2015

RSC Adv., 2015,5, 55808-55811

Synthesis of poly-functionalized imidazoles via vinyl azides annulation

J. Luo, W. Chen, J. Shao, X. Liu, K. Shu, P. Tang and Y. Yu, RSC Adv., 2015, 5, 55808 DOI: 10.1039/C5RA07320K

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