Issue 62, 2015

Effect of maleimide-functionalized gold nanoparticles on hybrid biohydrogels properties

Abstract

The role of well-dispersed gold nanoparticles as cross-linking agents in nanocomposite hydrogel formation was studied. Maleimide-coated gold nanoparticles were synthesized and used for Diels–Alder cycloaddition with furan modified gelatin. Hydrogel formation was aided by additional amide coupling of the modified gelatin with chondroitin sulfate. The cross-linking ability of the functionalized nanoparticles was evaluated and the final hydrogel properties were compared to those of a hybrid hydrogel containing inert-linker coated gold nanoparticles. The storage modulus of the nanoparticle cross-linked nanocomposites was 2.5–3 times compared to the controls. The presence of nanoparticles also affected the swelling properties, resulting in lower swelling ratios due to the formation of the more cross-linked structures. Conducted drug delivery experiments and the study of the light irradiation on the drug release behavior revealed promising features for the applications of nanocomposite polymer for drug delivery.

Graphical abstract: Effect of maleimide-functionalized gold nanoparticles on hybrid biohydrogels properties

Supplementary files

Article information

Article type
Paper
Submitted
15 Apr 2015
Accepted
29 May 2015
First published
29 May 2015

RSC Adv., 2015,5, 50268-50277

Author version available

Effect of maleimide-functionalized gold nanoparticles on hybrid biohydrogels properties

C. García-Astrain, I. Ahmed, D. Kendziora, O. Guaresti, A. Eceiza, L. Fruk, M. A. Corcuera and N. Gabilondo, RSC Adv., 2015, 5, 50268 DOI: 10.1039/C5RA06806A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements