Issue 60, 2015
From the journal:

RSC Advances

Fibril aggregates of the poly(glutamic acid)–drug conjugate†

Jingjing Laia  and  Yanbin Huang*a  

* Corresponding authors

a Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
E-mail: yanbin@tsinghua.edu.cn

Abstract

Polymer–drug conjugates are an important category of nanomedicine, and the aggregate size and shape are important for the applications. The poly(glutamic acid)–doxorubicin conjugate was found to form fibrillar aggregates with diameter about 40 nm and length up to tens of microns. The fibrils slowly dissociate and release the soluble conjugates at neutral pH condition.

Graphical abstract: Fibril aggregates of the poly(glutamic acid)–drug conjugate

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Article information

DOI
https://doi.org/10.1039/C5RA06755C
Article type
Communication
Submitted
15 Apr 2015
Accepted
26 May 2015
First published
27 May 2015

RSC Adv., 2015,5, 48856-48860

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Fibril aggregates of the poly(glutamic acid)–drug conjugate

J. Lai and Y. Huang, RSC Adv., 2015, 5, 48856 DOI: 10.1039/C5RA06755C

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