Issue 83, 2015
From the journal:

RSC Advances

Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy†

Xuefan Xu,a   Lei Zhang,a   Assogba G. Assanhou,ab   Lu Wang,a   Yidi Zhang,a   Wenyuan Li,c   Lingjing Xue,a   Ran Mo*a  and  Can Zhang*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China
E-mail: rmo@cpu.edu.cn, zhangcan@cpu.edu.cn

b UFR Pharmacie, Faculté des Sciences de la Santé, Université d'Abomey-calavi, 01 BP 188, Cotonou, Benin

c Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia

Abstract

Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.

Graphical abstract: Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

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Article information

DOI
https://doi.org/10.1039/C5RA06445G
Article type
Communication
Submitted
10 Apr 2015
Accepted
31 Jul 2015
First published
07 Aug 2015

RSC Adv., 2015,5, 67803-67808

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Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

X. Xu, L. Zhang, A. G. Assanhou, L. Wang, Y. Zhang, W. Li, L. Xue, R. Mo and C. Zhang, RSC Adv., 2015, 5, 67803 DOI: 10.1039/C5RA06445G

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