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Issue 49, 2015
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Coumarins as privileged scaffold for anti-inflammatory drug development

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Several literature reports had highlighted the significance of coumarin nucleus as a source of potential candidates for anti-inflammatory drug development. Various natural coumarins such as umbelliferone, scopoletin, visnadin, marmin and esculetin demonstrated potent anti-inflammatory activity through various mechanisms. Keeping in view the importance of naturally occurring coumarins, researchers have extensively explored these by synthesizing various derivatives as anti-inflammatory agents. The present review describes different synthetic modifications carried out on coumarin nucleus, assessment of their anti-inflammatory potential and structure–activity relationship (SAR) study, reported during 1992–2014. SAR may help medicinal chemists in rational design of future anti-inflammatory molecules based on coumarin scaffold.

Graphical abstract: Coumarins as privileged scaffold for anti-inflammatory drug development

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Publication details

The article was received on 30 Mar 2015, accepted on 20 Apr 2015 and first published on 20 Apr 2015

Article type: Review Article
DOI: 10.1039/C5RA05643H
RSC Adv., 2015,5, 38892-38905

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    Coumarins as privileged scaffold for anti-inflammatory drug development

    J. Grover and S. M. Jachak, RSC Adv., 2015, 5, 38892
    DOI: 10.1039/C5RA05643H

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