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Issue 60, 2015
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Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

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Abstract

In the present study, we designed a pH-responsive drug nanocarrier based on polyamidoamine-modified Fe3O4 nanoparticles coated by PEGylated starch-co-poly(acrylic acid). This carrier was used for the controlled release of doxorubicin as an anticancer drug model. The purpose of using the polyethylene glycol moiety is to generate a biostable nanocarrier in blood stream as it has been reported widely in the pharmaceutical literature. The use of a poly(acrylic acid) segment also provided pH-sensitivity to the polymer. Besides, the magnetic nanoparticles facilitate the cancer cell targeting with an external magnetic field located near the tumor site. This carrier was characterized by techniques such as FT-IR, 1H-NMR, UV-Vis, DLS, TGA, TEM, zeta potential, WAXD and VSM. Moreover, in vitro drug release profiles and cytotoxicity assays were investigated.

Graphical abstract: Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

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Publication details

The article was received on 06 Mar 2015, accepted on 11 May 2015 and first published on 01 Jun 2015


Article type: Paper
DOI: 10.1039/C5RA04040J
Citation: RSC Adv., 2015,5, 48586-48595
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    Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

    A. Pourjavadi, Z. M. Tehrani and S. H. Hosseini, RSC Adv., 2015, 5, 48586
    DOI: 10.1039/C5RA04040J

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