Issue 49, 2015
From the journal:

RSC Advances

Surface modification of neural electrodes with a pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo†

J. Y. Lee,‡*ab   Z. Z. Khaing,‡c   J. J. Siegeld  and  C. E. Schmidtac  

* Corresponding authors

a Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA

b School of Materials Science and Engineering, Gwangju Institute of Science and Engineering, Gwangju, South Korea
E-mail: jaeyounglee@gist.ac.kr

c Department of Biomedical Engineering, The University of Florida, Gainesville, FL, USA

d Center for Learning and Memory, The University of Texas at Austin, Austin, TX, USA

Abstract

Surfaces of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.

Graphical abstract: Surface modification of neural electrodes with a pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo

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Article information

DOI
https://doi.org/10.1039/C5RA03294F
Article type
Communication
Submitted
22 Feb 2015
Accepted
22 Apr 2015
First published
22 Apr 2015

RSC Adv., 2015,5, 39228-39231

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Surface modification of neural electrodes with a pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo

J. Y. Lee, Z. Z. Khaing, J. J. Siegel and C. E. Schmidt, RSC Adv., 2015, 5, 39228 DOI: 10.1039/C5RA03294F

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