Issue 37, 2015
From the journal:

RSC Advances

A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles†

Enrica Calce,a   Paola Ringhieri,b   Flavia Anna Mercurio,a   Marilisa Leone,ab   Valeria Bugatti,c   Michele Saviano,d   Vittoria Vittoriac  and  Stefania De Luca*ab  

* Corresponding authors

a Institute of Biostructures and Bioimaging, National Research Council, 80138 Naples, Italy
E-mail: stefania.deluca@cnr.it
Fax: +39-081-2536642
Tel: +39-081-2534514

b Department of Pharmacy, Interuniversity Centre for Research on Bioactive Peptides, CIRPeB, University of Naples “Federico II”, Italy

c Department of Industrial Engineering, University of Salerno, 84084 Fisciano (Sa), Italy

d Institute of Crystallography, National Research Council, Via Amendola 122/O, 70126 Bari, Italy

Abstract

New self-assembled nano-particles were developed by chemical conjugation of natural fatty acids to the backbone of hyaluronan (HA). The chemical structure and the self-association behavior of them were studied by FT-IR, NMR, fluorescence and dynamic light scattering. The HA derivatives form stable spherical shape aggregates, as assessed by transmission electron microscopy.

Graphical abstract: A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles

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Article information

DOI
https://doi.org/10.1039/C5RA03107A
Article type
Communication
Submitted
18 Feb 2015
Accepted
20 Mar 2015
First published
20 Mar 2015

RSC Adv., 2015,5, 29573-29576

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A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles

E. Calce, P. Ringhieri, F. A. Mercurio, M. Leone, V. Bugatti, M. Saviano, V. Vittoria and S. De Luca, RSC Adv., 2015, 5, 29573 DOI: 10.1039/C5RA03107A

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