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Issue 45, 2015
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Gallic acid: prospects and molecular mechanisms of its anticancer activity

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Abstract

Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer drugs and scientists explore various natural and artificial compounds to overcome this. Gallic acid (GA) is one of the phenolic acids found in many dietary substances and herbs used in ancient medicine. It possesses antiinflammatory, antioxidant, antiviral and antibacterial properties. The present review summarizes the anticancer activity of GA and its derivatives. Various in vitro and in vivo experiments of GA against a variety of cancer cell lines were reported. The previous studies show that the anticancer activity of GA is related to the induction of apoptosis through different mechanisms like generation of reactive oxygen species (ROS), regulation of apoptotic and anti-apoptotic proteins, suppression and promotion of oncogenes, inhibition of matrix metalloproteinases (MMPs) and cell cycle arrest depending upon the type of cancer investigated. Conclusively, GA and its derivatives may be considered as a potent drug for cancer treatment alone as well as in combination with other anticancer drugs to increase the efficiency of chemotherapy. However, there is still a need for more experimentation in knock-out animal models and human clinical trials to promote and place GA and its derivatives on the commercial market.

Graphical abstract: Gallic acid: prospects and molecular mechanisms of its anticancer activity

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Article information


Submitted
12 Feb 2015
Accepted
27 Mar 2015
First published
27 Mar 2015

RSC Adv., 2015,5, 35608-35621
Article type
Review Article
Author version available

Gallic acid: prospects and molecular mechanisms of its anticancer activity

A. P. Subramanian, A. A. John, M. V. Vellayappan, A. Balaji, S. K. Jaganathan, E. Supriyanto and M. Yusof, RSC Adv., 2015, 5, 35608
DOI: 10.1039/C5RA02727F

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