Issue 30, 2015

Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines

Abstract

A novel and efficient palladium catalyzed method was developed for the synthesis of wide range of pyrido[2,3-d]pyrimidines, using readily available β-bromovinyl/aryl aldehydes and 6-amino-1,3-dialkyluracils as the starting materials with good yields. This reaction proceeds via cascade imination/Buchwald–Hartwig cross coupling/cycloaddition reactions under microwave irradiation and solvent free conditions.

Graphical abstract: Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines

Supplementary files

Article information

Article type
Communication
Submitted
13 Jan 2015
Accepted
25 Feb 2015
First published
25 Feb 2015

RSC Adv., 2015,5, 23210-23212

Author version available

Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines

P. Saikia, G. Sharma, S. Gogoi and R. C. Boruah, RSC Adv., 2015, 5, 23210 DOI: 10.1039/C5RA00725A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements