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Issue 12, 2015
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Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

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Abstract

A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (2) designated chromomycin A5 (5). Chromomycin A5 displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI50 0.00073 μg mL−1) against a mini-panel of murine and human cancer cell lines.

Graphical abstract: Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

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Publication details

The article was received on 30 Oct 2014, accepted on 19 Dec 2014 and first published on 19 Dec 2014


Article type: Paper
DOI: 10.1039/C4RA16517A
Citation: RSC Adv., 2015,5, 9116-9122
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    Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

    G. R. Pettit, R. Tan, R. K. Pettit, D. L. Doubek, J. Chapuis and C. A. Weber, RSC Adv., 2015, 5, 9116
    DOI: 10.1039/C4RA16517A

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