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Issue 25, 2015

Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair

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Abstract

In this work we prepared two new hyaluronic acid (HA) based in situ forming hydrogels for the potential treatment of articular cartilage damages. In particular the amino derivative of HA (HA-EDA) and its graft copolymer with α-elastin (HA-EDA-g-α-elastin) were crosslinked, in mild physiological conditions via Michael-type addition, with α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) derivatized with divinylsulfone (DV). The swelling and degradation profile of the obtained hydrogels as well as the metabolic activity of incorporated bovine articular chondrocytes were investigated. Histological analysis and scanning electron microscopy (SEM) were performed to analyze the morphology of cells after scheduled times of incubation. Moreover the influence of the α-elastin on the elastic modulus of cell free and cell containing hydrogels has been studied through atomic force microscopy (AFM).

Graphical abstract: Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair

Supplementary files

Article information


Submitted
15 Dec 2014
Accepted
11 Feb 2015
First published
12 Feb 2015

RSC Adv., 2015,5, 19715-19723
Article type
Paper

Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair

C. Fiorica, F. S. Palumbo, G. Pitarresi, A. Gulino, S. Agnello and G. Giammona, RSC Adv., 2015, 5, 19715 DOI: 10.1039/C4RA16411C

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