Facile and diverse microwave-assisted synthesis of secondary propargylamines in water using CuCl/CuCl2†
Abstract
A highly efficient microwave-assisted three-component reaction between an aldehyde, a primary amine and an alkyne was developed using an inexpensive Cu(I)/Cu(II) catalytic system and water as solvent. A wide range of diversely substituted secondary propargylamines was prepared in good and high yields within a short period of time.