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Issue 20, 2015
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Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

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Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities. The combination of different pharmacophores in a pyrrole ring system has led to the formation of more active compounds. Pyrrole containing analogs are considered as a potential source of biologically active compounds that contains a significant set of advantageous properties and can be found in many natural products. The marketed drugs containing a pyrrole ring system are known to have many biological properties such as antipsychotic, β-adrenergic antagonist, anxiolytic, anticancer (leukemia, lymphoma and myelofibrosis etc.), antibacterial, antifungal, antiprotozoal, antimalarial and many more. Due to the diversity of these analogs in the therapeutic response profile, many researchers have been working to explore this skeleton to its maximum potential against several diseases or disorders. In this review, attempts have been made to disclose various tactical approaches to synthesize pyrrole and pyrrole containing analogs. The structure–activity relationship studies have been discussed along with their therapeutic applications which have been reported during last decade. Some molecules as the main components of the market and clinical trials have also been discussed.

Graphical abstract: Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

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Article information

03 Dec 2014
22 Jan 2015
First published
23 Jan 2015

RSC Adv., 2015,5, 15233-15266
Article type
Review Article
Author version available

Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

V. Bhardwaj, D. Gumber, V. Abbot, S. Dhiman and P. Sharma, RSC Adv., 2015, 5, 15233
DOI: 10.1039/C4RA15710A

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