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Issue 36, 2015
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Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: pyrimidine as an easily removable C–H directing group

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Abstract

Pyrimidine is successfully used as an easily removable C(sp2)–H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C–H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1H-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles.

Graphical abstract: Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: pyrimidine as an easily removable C–H directing group

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Article information


Submitted
24 Nov 2014
Accepted
12 Mar 2015
First published
13 Mar 2015

RSC Adv., 2015,5, 28292-28298
Article type
Paper
Author version available

Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: pyrimidine as an easily removable C–H directing group

G. Kumar and G. Sekar, RSC Adv., 2015, 5, 28292
DOI: 10.1039/C4RA15162C

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