Copper-catalyzed oxidative cyclization of arylamides and β-diketones: new synthesis of 2,4,5-trisubstituted oxazoles†
Abstract
A novel copper catalyzed approach to oxazoles via enamide intermediates was developed from benzamides and β-diketones. The successive condensation and cyclization reactions afforded various 2,4,5-trisubstituted oxazoles in good yields.