Bi(OTf)3-catalyzed C–H bond functionalization of azaarenes for the facile access to oxindoles featuring quaternary carbon centers

Abstract

The direct sp³ C–H bond functionalization of 2-alkyl azaarenes to isatylidene malononitriles has been achieved using Bi(OTf)₃ as the catalyst, resulting in a series of oxindoles containing an all-carbon quaternary center in moderate to good yields. This protocol provided an efficient and convenient method for the construction of potentially useful azaarene substituted oxindoles.